Is it more challenging for those who are overweight to rewire their brain?

This study found that the capacity for synaptic plasticity is reduced in people who are obese when compared to those of healthy weight.

Sui SX, Ridding MC, Hordacre B. Obesity is Associated with Reduced Plasticity of the Human Motor Cortex. Brain Sciences. 2020; 10(9):579. https://doi.org/10.3390/brainsci10090579